May-Thurner syndrome or iliac vein compression syndrome is deep vein thrombosis resulting from chronic compression of the left iliac vein against lumbar vertebrae by the overlying right common iliac artery. Historically, the treatment for patients with iliac vein compression syndrome has been anticoagulation therapy. When given alone, however, this therapy can be problematic because it prevents the propagation of the thrombus without eliminating the existing clot. Furthermore, it does not treat the underlying mechanical compression. Consequently, when deep vein thrombosis is treated with anticoagulation therapy alone, there is a significant chance that the patient will develop recurrent deep vein thrombosis or post thrombotic syndrome or both. Recently, both retrospective and prospective studies have suggested that endovascular management should be front-line treatment; endovascular management actively treats both the mechanical compression with stent placement and the thrombus burden with chemical dissolution. We report our case of 53y old male patient with May Thurner syndrome managed by endovascular treatment.