The purpose of this article is to present the early results of single centre trial using drug eluting beads loaded with chemotherapeutic agents for transarterial chemoembolization (TACE) in patients with un-resectable hepatocellular carcinoma. From December 2006 to March 2011, 50 patients (33 male and 17 female), with mean age 67.8 years (45-82) were treated by selective TACE using drug eluting beads (DEB) loaded with doxorubicin. The diameter of the treated lesions ranged from 3.5 to 11.5 mm (mean 52.5mm; maximum of 4 tumor nodules). Tumor response was evaluated by either multiphasic computed axial tomography (CT) or MRI according to the European Association for the Study of the Liver criteria. All of the procedures were technically successful, and there were no major complications. At 1-month follow-up, objective response was observed in 62%, then increased to 75% and 80% after second and third session of embolization. TACE with (DEB) loaded with doxorubicin was successfully repeated twice in 20 patients, whereas 5 patients underwent the procedure 3 times. Our initial single centre experience retrospective analysis demonstrates that TACE using (DEB) is feasible, is well tolerated, has a low complication rate, and is associated with promising tumor response. When complete tumor response in not achieved, additional treatments can be performed without difficulties.